Niclosamide sensitizes nasopharyngeal carcinoma to radiation by downregulating Ku70/80 expression

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Niclosamide sensitizes nasopharyngeal carcinoma to radiation by downregulating Ku70/80 expression

The aim of the present study was to investigate whether niclosamide could sensitize the nasopharyngeal carcinoma cells to radiation and further explore the underlying mechanisms. CCK-8 assay was used to determine the effect of niclosamide on the proliferation of NPC cells. Colony formation assay was used to evaluate the radiosensitizing effect of niclosamide on NPC cells. Flow cytometry analysi...

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miR-101 sensitizes human nasopharyngeal carcinoma cells to radiation by targeting stathmin 1

Radioresistance remains a major problem in the treatment of patients suffering from nasopharyngeal carcinoma (NPC). A better understanding of the mechanisms involved in the induction of radioresistance may provide strategies to improve NPC patients' response to therapy. The present study aimed to investigate the effect of microRNA (miR)-101 on the radioresistance of NPC cells. Analysis of miR-1...

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Oleuropein enhances radiation sensitivity of nasopharyngeal carcinoma by downregulating PDRG1 through HIF1α-repressed microRNA-519d

BACKGROUND Oleuropein (OL) is a well-known anti-oxidative agent and is shown to reduce the hypoxia-inducible factor 1 α (HIF1α) protein expression after radiation. The current study investigated the effects of OL on radiation response in nasopharyngeal carcinoma (NPC). METHODS Colony formation assay was performed to compare the radiation response in vitro. Xenograft mouse model was used to st...

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ژورنال

عنوان ژورنال: Journal of Cancer

سال: 2018

ISSN: 1837-9664

DOI: 10.7150/jca.20963